Laser photo-CIDNP NMR of pyridoxal phosphate and pyridoxyllysine residues: an extrinsic probe for non-aromatic amino acid residues in proteins |
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| Authors: | C L Lerman M Cohn |
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| Institution: | 1. Department of Pharmacology School of Pharmacy University of Georgia Athens, Georgia 30602 USA;2. Department of Veterinary Pathology School of Veterinary Medicine University of Georgia Athens, Georgia 30602 USA |
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| Abstract: | The interferon inducing agents, polyriboinosinic: polyribocytidylic acid and tilorone, and Freund's complete adjuvant cause a marked depression of several components of the hepatic mixed-function oxidase system. Separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and quantitation by fluorescence gel scanning of different molecular weight species of cytochrome P-450 indicate that the depressant effect of these agents on the apoprotein moieties of cytochrome P-450 is of a specific nature. |
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| Keywords: | Poly rIrC polyriboinosinic polyribocytidylic acid MFO mixed-function oxidase FA Freund's adjuvant SDS sodium dodecyl sulfate |
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