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Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells |
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| Authors: | Chella Perumal Palanisamy Sivakumar Pethanan Gopinath Gurulingam Vincent Karthigeyan Murugesan Ananthavalli Ramachandran Ramu Sivanandam Mani Panagal |
| Institution: | 1.State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China;2.Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India;3.Department of zoology, Arumugam Pillai Seethai Ammal College, Tiruppathur, Tamil Nadu, India;4.Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamil Nadu - 612503, India |
| Abstract: | It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in C. trifoliatreated A2780 cell lines for further consideration as a chemotherapeutic agents. |
| Keywords: | Cayratia trifolia CXCR4 and HER2 protein expression Metastatic signalling Anti-ovarian cancer activity |