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Expression of the Gm1-Species, [NeuN]-GM1, in a Case of Human Glioma
Authors:Fredman  Pam  Månsson  Jan-Eric  Dellheden  Birgitta  Boström  Kerstin  Holst  Hans Von
Institution:(1) Institute of Clinical Neuroscience, Dept of Neurochemistry, Göteborg University, Sweden;(2) Dept of Forensic Medicine, Sweden;(3) Dept of Neurosurgery, Karolinska hospital, Stockholm, Sweden;(4) Department of Neurochemistry,SU/Mölndal, S-431 80 Mölndal, Sweden
Abstract:Altered glycosylation is a common feature in tumors of various kind and particular interest has been focused on the expression of tumor-associated gangliosides. We have previously identified some human glioma-associated gangliosides and in this study yet another, not previously described, ganglioside has been isolated. The ganglioside was prepared from human glioma tissue taken at autopsy. The new ganglioside bound cholera-toxin B-subunit and its structure was confirmed by fast atom bombardment—mass spectrometry to be NeuN-GM1 (II3NeuNH2-GgOse4Cer). In the dissected tumor specimen, the concentration of NeuN-GM1 was 0.1 mgrmol/g wet weight and accounted for approximately 20% of the monosialoganglioside fraction. Normal human brain tissue specimens (n = 10) did not contain detectable (>0.5 nmol/g wet weight of tissue) amounts of NeuN-GM1, indicating that this ganglioside might be associated with human glioma. However, none of the 17 other tumour specimens reveal any detectable amounts of this ganglioside. In conclusion, NeuN GM1 is a glioma-associated ganglioside but its exceptional expression limits its relevance as a molecule involved in general tumor biology.
Keywords:GM1-ganglioside  ganglioside-analogues  tumor-gangliosides  glioma  tumor growth
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