Cathepsin B inhibitory peptides derived from beta-casein |
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| Authors: | Lee H S Lee K J |
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| Affiliation: | Department of Microbiology, College of Natural Sciences, and Research Centre for Molecular Microbiology, Seoul National University, 151-742, Seoul, South Korea. |
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| Abstract: | Two cathepsin B inhibitory peptides were isolated from a commercial pancreatic digest of casein. The peptides were identified as the Pro-Phe-Pro-Gly-Pro-Ile and the Gly-Pro-Phe-Pro-Ile corresponding to the sequence 61-66 and 203-207 of bovine beta-casein. These peptides showed competitive inhibition for cathepsin B with the K(i) values of 2.31 and 3.30 mM, respectively. Two related analogues, Tyr-Pro-Phe-Pro-Gly-Pro-Ile and Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile, were synthesized but their cathepsin B inhibitory activity was not detected. |
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