Sipaucins A-C,sesquiterpenoids from Siparuna pauciflora |
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| Authors: | Jenett-Siems Kristina Kraft Carola Siems Karsten Jakupovic Jasmin Solis Pablo N Gupta Mahabir P Bienzle Ulrich |
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| Institution: | Institut für Pharmazie (Pharmazeutische Biologie), Freie Universit?t Berlin, K?nigin-Luise-Str. 2-4, D-14195 Berlin, Germany. kjsiems@zedat.fu-berlin.de |
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| Abstract: | The phytochemical investigation of the leaves of Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids-nor-boldine, boldine, laurotetanine, and N-methyl-laurotetanine-were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of Plasmodium falciparum (PoW, Dd2) showed a moderate activity of nor-boldine. |
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| Keywords: | Siparuna pauciflora Monimiaceae Sesquiterpenoids Aporphine alkaloids Plasmodium falciparum |
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