Identification of a Novel Penicillin-Binding Protein from Helicobacter pylori |
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| Authors: | Partha Krishnamurthy Mary H. Parlow John Schneider Stephanie Burroughs Catherine Wickland Nimish B. Vakil Bruce E. Dunn Suhas H. Phadnis |
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| Affiliation: | Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. |
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| Abstract: | The Helicobacter pylori genome encodes four penicillin-binding proteins (PBPs). PBPs 1, 2, and 3 exhibit similarities to known PBPs. The sequence of PBP 4 is unique in that it displays a novel combination of two highly conserved PBP motifs and an absence of a third motif. Expression of PBP 4, but not PBP 1, 2, or 3, is significantly increased during mid- to late-log-phase growth. |
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