Approaches to Enhance the Binding Affinity and Nuclease Stability of Triplex Forming Oligonucleotides |
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| Authors: | K. Jayaraman R. H. Durland T. S. Rao G. R. Revankar V. Bodepudi N. Chaudhary |
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| Affiliation: | Triplex Pharmaceutical Corporation, 9391 Grogans Mill Road , The Woodlands, TX, 77380, U.S.A. |
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| Abstract: | Abstract The ability of simple azole nucleosides to promote antiparallel triplex formation at non-homopurine duplex targets was explored. It was also shown that spermidine-cholesterol conjugation is effective in enhancing cellular uptake and stability of oligonucleotides. |
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