Synthesis of the tBuSATE Pronucleotide of AZT by Two Different Synthetic Approaches |
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| Authors: | M Lannuzel D Egron J-L Imbach G Gosselin C Périgaud |
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| Institution: | Laboratoire de Chimie Bioorganique, U.M.R. 5625 C.N.R.S-U.S.T.L. , Université de Montpellier II , CC 008, Place E. Bataillon, 34095, Montpellier Cedex 05, France |
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| Abstract: | Abstract A large scale synthesis of the tBuSATE pronucleotide of AZT was required for in vivo studies. A comparative synthesis of this derivative by phosphoramidite and monophosphate approaches is reported. |
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