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The N1-(3′-Deoxythymidin-3′-yl)-N2-cyano-N3-(5′-deoxythymidin-5′-yl) Guanidine Dimeric Building Block in Automated DNA Synthesis and Mass Spectrometric Analysis of Its Integrity |
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| Authors: | C Pannecouque J Rozenski B Devreese J Van Beeumen A Van Aerschot P Herdewijn |
| Institution: | 1. Laboratory of Medicinal Chemistry , Rega Institute for Medical Research, Katholieke Universiteit Leuven , Minderbroedersstraat, 10, B-3000, Leuven, Belgium;2. Department of Biochemistry, Physiology and Microbiology , Universiteit Gent, K. L. Ledeganckstraat , 35, B-9000, Gent, Belgium |
| Abstract: | Abstract Nucleoside dimers with an N-cyanoguanidine linkage were synthesized and incorporated in oligonucleotides on an automated DNA synthesizer. The integrity of the dimer was investigated using mass spectrometry. |
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