Derivatives of L-Adenosine and L-Guanosine as Substrates for Human Deoxycytidine Kinase |
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| Authors: | G. Gaubert G. Gosselin J-L. Imbach S. Eriksson G. Maury |
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| Affiliation: | 1. Laboratoire de Chimie Bioorganique, UMR 5625 du CNRS , Université Montpellier II , Place E. Bataillon, 34095, Montpellier Cedex 5, France;2. Swedish University of Agricultural Sciences, Department of Veterinary Medical Chemistry, the Biomedical Center , Box 575, S-75123, Uppsala, Sweden |
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| Abstract: | Abstract A series of analogues of L-adenosine and of L-guanosine, including ß-L-dA, ß-L-Ado, ß-L-araA, and ß-L-dG, have been shown to be substrates of human deoxycytidine kinase thus demonstrating the complete lack of enantioselectivity of this enzyme. |
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