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The Synthesis and Antiviral Activity of Some New S-Adenosyl-L-homocysteine Derivatives and Their Nucleoside Precursors |
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| Authors: | Pawel Serafinowski Erwin Dorland Jan Balzarini Erik De Clercq |
| Affiliation: | 1. CRC Centre for Cancer Therapeutics , Institute of Cancer Research , 15 Cotswold Road, Sutton, Surrey, SM2 5NG, U. K.;2. Rega Institute for Medical Research, Katholieke Universiteit Leuven , Minderbroedersstraat, 10, B-3000, Leuven, Belgium |
| Abstract: | Abstract S-Adenosyl-L-homocysteine (SAH) and some of its analogues are potent inhibitors of transmethylation reactions catalysed by S-adenosyl methionine dependent methyltransferases.1 |
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