Synthesis and Antiviral Activity of D- and L-Isodideoxy Nucleosides with Exocyclic Methylene |
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| Authors: | Lak Shin Jeong Su Jeong Yoo Hyung Ryong Moon Moon Woo Chun Chong-Kyo Lee |
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| Institution: | 1. Laboratory of Medicinal Chemistry , College of Pharmacy, Ewha Womans University , Seoul, 120-750, Korea;2. College of Pharmacy, Seoul National University , Seoul, 151-742, Korea;3. Pharmaceutical Screening Center , Korea Research Institute of Chemical Technology , Daejon, 305-606, Korea |
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| Abstract: | Abstract Novel d- and l-isodideoxynucleosides were synthesized starting from d- and l-xylose and evaluated for antiviral activities against HIV-1, HSV-1, HSV-2, HBV and HCMV, respectively. |
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