The Synthesis of Novel Transition State Analogues Related to Imidazole and Purine Nucleotides Involved in the De novo Biosynthesis of Purines |
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| Authors: | A Scott Frame Richard H Wightman G Mackenzie |
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| Institution: | 1. Department of Chemistry , Heriot-Watt University , Edinburgh, EH14 4AS, UK.;2. School of Chemistry, University of Hull , Hull, HU6 7RX, UK. |
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| Abstract: | Abstract 5-Amino-4-sulphonamidoimidazole ribofuranosyl nucleosides and a related imidazothiadiazine dioxide nucleoside have been synthesized as potential inhibitors of enzymes involved in the de novo biosynthesis of purine nucleotides. |
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