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Stereospecific Synthesis and Antiviral Activities of β-L-2′,3′-Dideoxy-5-chloropyrimidine Nucleoside Derivatives |
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| Authors: | C Pierra G Gosselin J-P Sommadossi A Faraj E De Clercq J Balzarini |
| Institution: | 1. Laboratoire de Chimie Bioorganique, UMR CNRS 5625 , Université de Montpellier II , Montpellier Cedex 5, France;2. Department of Pharmacology , University of Alabama at Birmingham , Birmingham, AL, 35294-0019, USA;3. Rega Institute for Medical Research, Katholieke Universiteit Leuven , B-3000, Leuven, Belgium |
| Abstract: | Abstract Several 5-chlorouracil and 5-chlorocytosine β-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examinated in cell culture. |
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