Postsynthetic Transformations of Oligodeoxynucleotides Originated at 6-Methylthio-purine Site |
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| Authors: | Artur Burdzy Bohdan Skalski Ewa Bia? Andrzej Kowalewski Stefan Paszyc Rysard W Adamiak |
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| Institution: | 1. Faculty of Chemistry , Adam Mickiewicz University , Poznań;2. Institute of Bioorganic Chemistry, Polish Academy of Sciences , Poznań, Poland |
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| Abstract: | Abstract New route to oligodeoxynucleotides labeled with fluorescent luminarine was explored. Regioselective oxidation of 6-methylthio-purines to 6-methylsulphoxides reactive toward pyridine was achieved. Upon UV irradiation of 6-pyridinium-purines oligonucleotide cleavage instead of phototransformation to luminarine was observed. |
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