Synthesis of cis-Disubstituted Cyclobutenyl Nucleoside Analogues |
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| Authors: | M-E. Gourdel-Martin F. Huet |
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| Affiliation: | Laboratoire de Synthèse Organique, ESA 6011, Faculté des Sciences , Université du Maine , Avenue Olivier Messiaen, 72085, Le Mans Cedex 9, France |
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| Abstract: | Abstract cis-Disubstituted cyclobutene nucleosides analogues were prepared by a linear synthesis starting from cis-cyclobutene dicarboxylic anhydride. This strategy involved mild reaction conditions with intent to restrict the thermal electrocyclic ring opening into (Z,E)-dienes. |
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