In Search of Acyclic Analogues as Universal Nucleosides in Degenerate Probes |
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| Authors: | A Van Aerschot C Hendrix G Schepers N Pillet P Herdewijn |
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| Institution: | Laboratory of Medicinal Chemistry , Rega Institute for Medical Research , Minderbroedersstraat, 10, B-3000, Leuven, Belgium |
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| Abstract: | Abstract Five acyclic nucleoside analogues with unnatural base moieties have been synthesized of which three successfully were incorporated into oligonucleotides. The acyclic analogue containing the base 5-nitroindazole was the least discriminating and should be further pursued for use as a universal nucleoside analogue. |
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