Synthesis of Peptide Nucleic Acid Monomers |
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| Authors: | L Kovács Z Timár B Penke |
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| Institution: | Department of Medicinal Chemistry , A. Szent-Gy?rgyi Medical University , Dóm tér 8., H-6720, Szeged, Hungary |
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| Abstract: | Abstract The chemical synthesis of peptide nucleic acid (PNA) monomers is described using Fmoc (backbone), anisoyl (cytosine, adenine), 4-tert-butylbenzoyl (cytosine) and isobutyryl/diphenylcarbamoyl (guanine) protecting group combinations. For the guanine monomer the alkylation was realized both in a Mitsunobu DIAD, triphenylphosphine or (4-dimethylaminophenyl)diphenylphosphine, tert-butyl glycolate] and in a low-temperature, sodium-hydride mediated alkylation (tert-butyl bromoacetate) to give the N9 -substituted derivative. |
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