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Synthesis and Biological Application of a New Heterodinucleotide with Both Anti-HSV and Anti-HIV Activity |
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| Authors: | Palmarisa Franchetti Ghassan Abu Sheikha Loredana Cappellacci Mario Grifantini Emanuela Balestra Carlo-Federico Perno |
| Institution: | 1. Dipartimento di Scienze Chimiche , Università di Camerino , 62032, Camerino, Italy;2. Dipartimento di Medicina Sperimentale e Scienze Biochimiche , Università di Roma “Tor Vergata” , 00133, Roma, Italy |
| Abstract: | Abstract A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication. |
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