Synthesis and Broad-Spectrum Antiviral Activity in Mice of Certain Alkyl,Alkenyl and Ribofuranosyl Derivatives of 7-Deazaguanine |
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| Authors: | G. R. Revankar T. S. Rao K. Ramasamy D. F. Smee |
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| Affiliation: | 1. Triplex Pharmaceutical Corp. , 9391 Grogans Mill Rd., The Woodlands, TX, 77380;2. ICN Nucleic Acid Research Inst. , 3300 Hyland Ave., Costa Mesa, CA, 92626 |
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| Abstract: | Abstract A series of alkyl, alkenyl and β-D-ribofuranosyl derivatives of 7-deazaguanine were synthesized and their ability to inhibit certain RNA virus infections was assessed in mice. 8-Chloro-7-deazaguanosine (6) protected the majority of mice infected intraperitoneally (i.p.) with benzi, encephalomyocarditis, San Angelo, or Semliki Forest virus at doses as low as 50 mg/kg/day. It was also orally active. |
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