Use of Phenylacetyl Disulfide (PADS) in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates |
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| Authors: | Zacharia S Cheruvallath Patrick D Wheeler Douglas L Cole Vasulinga T Ravikumar |
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| Institution: | Isis Pharmaceuticals , 2292 Faraday Avenue, Carlsbad, CA, 92008 |
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| Abstract: | Abstract Investigations into the use of phenylacetyl disulfide (PADS) as an efficient sulfur transfer agent in the solid phase synthesis of oligodeoxyribonucleotide phosphorothioates showed that under suitable solvent conditions, this relatively inexpensive reagent rapidly and efficiently sulfurizes internucleotide phosphite linkages. |
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