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Synthesis and Anti-HIV Evaluation of 7-Deaza Analogues of Carbovir |
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| Authors: | Michel Legraverend Anne-Marie Aubertin Georges Obert Christiane Huel Emile Bisagni |
| Institution: | 1. Institut Curie, Section de Biologie, Centre Universitaire , 91405, Orsay, Cedex, France;2. URA 1387 CNRS, Université Louis Pasteur , 3, rue Koeberle, 67000, Strasbourg, France;3. U 74 INSERM, Université Louis Pasteur , 3, rue Koeberle, 67000, Strasbourg, France;4. U 350 INSERM, Université Louis Pasteur , 3, rue Koeberle, 67000, Strasbourg, France |
| Abstract: | Abstract Three analogues of Carbovir 1 have been synthesized and evaluated for antiviral activity in vitro. Anti-HIV-1 and anti-HIV-2 activities have been observed with 7-deaza analogues 3 and 5 of 1. Compound 5 was about ten times more potent than 3 against HIV-1 and HIV-2 on different cell lines. |
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