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Synthesis of a New Analog of Thymidine for In Vivo Non-radioactive Labeling of DNA |
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| Authors: | Ch. Rodríguez-Tanty R. Pérez J. Miranda H. Vélez-Castro A. Rosado A. Macias |
| Affiliation: | 1. Organic Chemistry Department , National Center for Scientific Research , PO Box 6880, Havana, Cuba;2. Molecular Biology Department , National Center for Scientific Research , PO Box 6880, Havana, Cuba |
| Abstract: | Abstract The introduction of 6-(p-bromobenzoylamino)caproyl radical in the methyl group of 2′-O-deoxythymidine is described. In vivo incorporation of this nucleoside to DNA was determined using a monoclonal antibody that recognized the radical. |
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