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Spectroscopic Characterization of the Decadeoxynucleotide Duplex Modified with Dichloroethylenediamineplatinum(II) |
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| Authors: | Hidehito Urata Masayuki Urata Masao Akagi Hidekazu Hiroaki Seiich Uesugi |
| Institution: | 1. Osaka University of Pharmaceutical Sciences , 2-10-65 Kawai, Matsubara, Osaka, 580;2. Faculty of Pharmaceutical Sciences, Osaka University , 1-6 Yamadaoka, Suita, Osaka, 565, Japan;3. Department of Molecular Genetics , Nippon Roche Research Center , 200 Kajiwara, Kamakura, Kanagawa, 247, Japan;4. Yokohama National University, Faculty of Engineering , 156 Tokiwadai, Hodogaya-ku, Yokohama, 240, Japan |
| Abstract: | Abstract We investigated the structure of a decadeoxynucleotide duplex which was modified with Dichloroethylenediamineplatinum(II) (PtCl2(en)) at the central GG site by using some spectroscopic techniques. The results suggest that the DNA structural changes induced by binding of PtCl2(en) are quite similar to those of cisplatin. |
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