Evidence for the Involvement of the Small Subunit of HIV-1 Reverse Transcriptase (RT) in the TSAO-Resistance |
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| Authors: | Heidi Jonckheere Jean-Marc Taymans Jan Balzarini Sonsoles Veláazquez Maria Jose Camarasa Jan Desmyter |
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| Affiliation: | 1. Rega Institute for Medical Research, Katholieke Universiteit Leuven , Minderbroedersstraat, 10, B-3000, Leuven, Belgium;2. Instituto de Quimica Medica (CSIC) , Juan de la Cierva 3, E-20006, Spain |
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| Abstract: | Abstract By introducing the TSAO-resistance mutation 138Glu→Lys in only the p51 subunit of HIV-1 RT, we obtained compelling evidence for a structural and functional role of the p51 subunit in the sensitivity and/or resistance of the enzyme to the TSAO-derivatives. |
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