Synthesis of a New Hydroxyamino Linked Thymidine Dimer via a Radical C-C Bond Formation |
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| Authors: | Yogesh S. Sanghvi P. Dan Cook |
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| Affiliation: | Medicinal Chemistry Department , Isis Pharmaceuticals , 2292 Faraday Avenue, Carlsbad, California, 92008, U.S.A. |
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| Abstract: | Abstract An efficient synthesis of a thymidine nucleoside dimer [T-3′-β-O-N(CH3)-CH2-5′-T] has been accomplished via an intermolecular radical coupling reaction. The novel dimer contains an achiral and neutral backbone linkage which may have potential application in constructing backbone modified antisense oligonucleosides. |
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