Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) |
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| Authors: | S. Hatse J. Balzarini E. De Clercq |
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| Affiliation: | Laboratory of Virology and Experimental Chemotherapy , Rega-Institute for Medical Research, Katholieke Universiteit Leuven , Belgium |
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| Abstract: | Abstract 9-(2-Phosphonylmethoxyethyl)adenine (PMEA), the prototype compound of a well-defined structural class of potent and selective anti-retroviral agents, was found to be endowed with long-lasting and dose-dependent differentiation-inducing properties in human erythroleukemia K562 cell cultures. |
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