Oligonucleotide Conjugates: Alteration of the Pharmacokinetic Properties of Antisense Agents |
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| Authors: | Muthiah Manoharan Kathleen L. Tivel Laura K. Andrade V. Mohan Thomas P. Condon C. Frank Bennett |
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| Affiliation: | Isis Pharmaceuticals , Carlsbad, CA, 92008, USA |
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| Abstract: | Abstract Cholic acid, cholesterol, several polyamines and polyethylene glycols were conjugated to antisense oligonucleotides targeted to human or murine intercellular adhesion molecule-1 (ICAM-1) mRNA to study their effects on cellular absorption. |
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