Nucleopeptidic Bioconjugates Containing a Sulfamide Bridge: Linkage via the Mitsunobu Reaction |
| |
Authors: | Marc Critonl Georges Dewyntert Nourreddine Aouf Jean-Louis Montero Jean-Louis Imbach |
| |
Affiliation: | 1. Laboratoire de Chimie bio-organique (URA 488) Université des Sciences et Techniques du Languedoc , Place E. Bataillon, 34065, Montpcllier cedex, 05, France;2. Laboratoire de Chimie Biomoléculaire (LIRA 1111) Université des Sciences et Techniques du Languedoc , Place E. Bataillon. 34065, Montpcllier cedex, 05, France |
| |
Abstract: | Abstract The synthesis of compounds connecting unprotected 2′-deoxyribonucleosides (T,dC,dG,dA) with N-Boc sulfamoyl derivatives of natural aminoacid esters (Phe, Asp) was carried out by Mitsunobu reaction, using regiospecific coupling. The created link was a priori non-hydrolyzable in biological conditions. |
| |
Keywords: | |
|
|