Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits |
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| Authors: | G Ceulemans K Khan A Van Schepdael P Herdewijn |
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| Institution: | Rega Institute for Medical Research, Laboratory of Medicinal Chemistry , Faculty of Pharmacy Katholieke Universiteit Leuven , B-3000, Leuven, Belgium |
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| Abstract: | Abstract Reaction of N-Boc-L-homoserine benzylester with N3 -benzoylthymine under Mitsunobu conditions afforded N-Boc-L-α-amino-γ-N3 -benzoylthymine butyric acid benzylester. After removal of the N-benzoyl and O-benzyl protecting group, this compound was used in solution phase peptide synthesis. |
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