Synthesis and Testing of New Modified Nucleosides |
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| Authors: | Michael E Jung Christopher J Nichols Oliver Kretschik Yue Xu |
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| Institution: | Department of Chemistry and Biochemistry , University of California , Los Angeles, California, 90095-1569 |
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| Abstract: | Abstract New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2′,3′-dideoxy isonucleosides 2abc (both the oxa and thia analgoues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4. |
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