Synthesis and Antiviral Activities of 1,3-Oxathiolanyl Nucleosides with 5-Hydroxymethyl Substituent |
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| Authors: | Moon Woo Chun Sung Pil Choi Myong Jung Kim Chol Joon Bae Hyung Ryong Moon Hee-Doo Kim |
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| Affiliation: | 1. College of Pharmacy, Seoul National University , Seoul, 151-742;2. Laboratory of Medicinal Chemistry , College of Pharmacy, Ewha Womans University , Seoul, 120-750, Korea;3. College of Pharmacy, Sookmyung Women's University , Seoul, 140-742, Korea |
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| Abstract: | Abstract Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from d-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV. |
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