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Design and Biological Evaluation of New Mechanismbased Inhibitors of S-Adenosyl-L-homocysteine Hydrolase |
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| Authors: | Stanislaw F. Wnuk Chong-Sheng Yuan Ronald T. Borchardt J. Robins Morris |
| Affiliation: | 1. Department of Chemistry , Florida International University , Miami, FL, 33199;2. Department of Chemistry and Biochemistry , Brigham Young University , Provo, UT, 84602;3. Department of Biochemistry , University of Kansas , Lawrence, KS, 66047 |
| Abstract: | Abstract Geminal dihalohomovinyl 2 and haloacetylenic 4 analogs derived from adenosine were prepared. These compounds exhibited type II (covalent) mechanism-based inactivation of S-adenosyl-L-homocysteine hydrolase. |
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