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3′-C-Hydroxymethylthymidine: Synthesis and Incorporation into Oligodeoxynucleotide Analogues |
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| Authors: | Pia N⊘ncgaard J⊘rgensen Margit L Svendsen Claus Nielsen Jesper Wengel |
| Institution: | 1. Department of Chemistry , Odense University , DK-5230, Odense M, Denmark;2. Retrovirus Laboratory, Department of Virology, States Seruminstitut. Artillerivej , 5, DK-2300, Copenhagen, Denmark |
| Abstract: | Abstract The stereoselective synthesis of 3′-C-hydroxymethylthymidine (5) in five steps from thymidine has been accomplished and this nucleoside has been incorporated into oligodeoxynucleotides (ODNs) in different ways. |
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