Synthesis of 2-Chloro-6-aryloxy- and 2-Chloro-6-alkoxyarylpurines and Their Properties in the Purine Nucleoside Phosphorylase (PNP) System |
| |
| Authors: | A Bzowska L Magnowska B Wielgus-kutrowska Z Kazimierczuk |
| |
| Institution: | Department of Biophysics , Institute of Experimental Physics, University of Warsaw , Z˙wirki i Wigury 93, 02 089, Warsaw, Poland |
| |
| Abstract: | Abstract A series of 2-chloro-6-aryloxy- and 2-chloro-6-alkoxyarylpurines was synthesized and their kinetic properties in the purine nucleoside phosphorylase (PNP) system were determined. All compounds showed inhibitory activity (IC50 in the range 0.5-76 μM) vs. hexameric (“high-molecular weight”) PNP from E. coli. By contrast, no inhibition vs. trimeric Cellulomonas PNP was detected. |
| |
| Keywords: | |
|
|
