Design and Synthesis of Regioisomeric Analogues of a Specific Anti-HIV-1 Agent 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) |
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| Authors: | Hiromichi Tanaka Masanori Baba Emiko Takahashi Kouichiro Matsumoto Atsushi Kittaka Richard T Walker |
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| Institution: | 1. School of Pharmaceutical Sciences, Showa University , Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan;2. Fukushima Medical College , Fukushima, 960-12, Japan;3. School of Chemistry , University of Birmingham , Birmingham, B15 2TT, United Kingdom |
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| Abstract: | Abstract Regioisomeric analogues of the anti-HIV-1 lead 1-(2-hydroxy-ethoxy)methyl]-6-(phenylthio)thymine (1: HEPT) have been synthesized. These compounds, having an ethoxymethyl side chain at C-5 and an ethyl group at the N-1 position of the uracil ring, also possess activity against HIV-1. |
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