Synthesis of 6-Aza- & 6-Methyl-pyrimidine Ribonucleoside Phosphoramidites and Their Incorporation in Hammerhead Ribozymes |
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| Authors: | Leonid Beigelman Alexander Karpeisky Nassim Usman |
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| Affiliation: | Department of Chemistry and Biochemistry Ribozyme Pharmaceuticals Inc. , 2950 Wilderness Place, Boulder, CO, 80301, USA |
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| Abstract: | Abstract The synthesis of phosphoramidites of 6-modified pyrimidine ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described. |
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