Chemical and Enzymatic Synthesis of 2′-Deoxy-iso-inosine and Its Incorporation into DNA |
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| Authors: | Jean-Jacques Beaussire Sylvie Pochet |
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| Institution: | Unité de Chimie Organique, URA-CNRS 487, Département de BGM , Institut Pasteur, 28, rue du Dr Roux , 75724, Paris Cedex |
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| Abstract: | Abstract Two procedures for the preparation of 2′-deoxy-iso-inosine (1) are presented. Synthesis of 3′-phosphoramidite (7) and 3′-phosphonate (8) derivatives are described, as well as an oligodeoxynucleotide containing iso-I. |
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