Antiviral Activity of Selected Nucleoside Analogues Against Human Herpes Virus Type 6 |
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| Authors: | D Reymen L Naesens J Balzarini A Holy E De Clercq |
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| Institution: | 1. Rega Institute for Medical Research, Katholieke Universiteit Leuven , Leuven, Belgium;2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Prague, Czech Republic |
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| Abstract: | Abstract HHV-6 was evaluated in vitro for its susceptibility to a broad range of nucleoside analogues. PFA and several acyclic nucleoside phophonates emerged as the most potent inhibitors of HHV-6 replication as monitored by a newly developed immunofluorescence / flow cytometric assay as well as by microscopical evaluation of their inhibitory effect on HHV-6-induced cytopathogenicity. |
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