益生菌防治特应性皮炎的研究进展

特应性皮炎(atopic dermatitis,AD)是会反复发作、具有明显遗传倾向性的慢性炎症性皮肤病,发病率逐年增高.AD的发病机制主要为遗传性或获得性皮肤屏障受损引起的皮肤微生态失衡和变应原渗漏,激活对应的炎症反应,造成"屏障受损-炎症反应"的恶性循环.AD的传统治疗方法多采用糖皮质激素和免疫抑制剂,但其副作用的...

Probiotics in the prevention and treatment of atopic dermatitis

Atopic dermatitis (AD) is a recurrent, chronic and inflammatory cutaneous disease with a clear genetic predisposition, and its incidence rate is increasing year by year. The main pathogenesis of AD is skin microdysbiosis and allergen leakage caused by hereditary or acquired cutaneous barrier damage, which activate the corresponding inflammatory reaction, resulting in the vicious circle of "barrier damage-inflammatory reaction". The traditional treatment of AD is corticosteroid and immunosuppressants. Recent studies have revealed that probiotics are effective in the treatment of AD. Probiotics can reshape the gut-skin axis by altering the skin or intestinal microbiota and repair of the skin barrier, resulting in stopping the cycle of AD progression and restoring healthy skin homeostasis.