Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides,Potential Oral Iron Chelators |
| |
Authors: | Gang Liu Fred W. Bruenger Amy M. Barrios Scott C. Miller |
| |
Affiliation: | Division of Radiobiology, School of Medicine, University of Utah , Bldg 585, Salt Lake City, UT, 84112, U.S.A. |
| |
Abstract: | Abstract Several ribonucleosides, named 2-alkyl-3-hydroxy-1-(β-D-ribofuranosyl or pyranosyl)-4-pyridinones, were synthesized in good yield. The method provides a useful means to obtain α-ketohydroxypyridin derivatives with different sugar moieties that, if used as drugs, might enhance their absorption from the intestine and certain other desirable pharmacological properties. |
| |
Keywords: | |
|
|