Effects of cycloSal-D4TMP Derivatives in H9 Cells with Induced AZT Resistance Phenotype |
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| Authors: | B. Gröschel C. Meier R. Zehner J. Cinatl H. W. Doerr J. Cinatl Jr. |
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| Affiliation: | 1. Institute of Medical Virology, Johann Wolfgang Goethe University , Sandhofstraβe 2-4, 60528, Frankfurt/M., Germany;2. Institute of Organic Chemistry, University of Würzburg , Germany;3. Center of Legal Medicine , Johann Wolfgang Goethe University , Frankfurt/M., Germany;4. Institute of Medical Virology, Johann Wolfgang Goethe University , Sandhofstraβe 2-4, 60528, Frankfurt/M., Germany;5. Center of Pediatrics, Department of Hematology and Oncology , Johann Wolfgang Goethe University , Frankfurt/M., Germany |
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| Abstract: | Abstract Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression. |
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