Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions |
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| Authors: | Y Kloog I Ambar E Kochva Z Wollberg A Bdolah M Sokolovsky |
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| Institution: | Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel. |
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| Abstract: | Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle. |
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