Effect of polysaccharides on biological activity of human lactoferrin |
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| Authors: | N. M. Mestechkina O. A. Bezborodova A. V. Il’ina A. N. Levov S. Yu. Kleimenov E. R. Nemtsova R. I. Yakubovskaya V. D. Shcherbukhin V. P. Varlamov |
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| Affiliation: | 1.Bach Institute of Biochemistry,Russian Academy of Sciences,Moscow,Russia;2.Herzen Cancer Research Institute,Moscow,Russia;3.Bioengineering Center,Russian Academy of Sciences,Moscow,Russia;4.Kol’tsov Institute of Developmental Biology,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | The influence of neutral and ionic polysaccharides on the antioxidant (AOA) and detoxifying activities of lactoferrin (LF) and the duration of its circulation in the body was studied. In addition to natural polymers, we studied chitosan synthetic derivatives with different functional groups. On the basis of AOA test, five polysaccharides were selected. The study of the detoxifying effect of LF in two models of induced toxicity revealed polysaccharides that maintained or increased the detoxifying activity of LF. We established that the formation of a complex of lactoferrin with two galactomannans and succinyl chitosan caused positive changes in LF properties: the detoxifying activity of the protein remained unchanged or increased, whereas its elimination from the body was decelerated. |
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