PAF-acether in AK-5 tumour cells |
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| Authors: | G K Marathe T P Krishnakantha C J D'Souza |
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| Institution: | Department of Studies in Biochemistry, University of Mysore, India. |
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| Abstract: | PAF-Acether fraction derived from stimulated AK-5 tumour cells, aggregated human platelets. The platelet aggregating ability increased linearly with increasing concentration of the stimulant, calcium ionophore A23187, and reached a maximum at 6 microM in 25 minutes. This factor had biological and chemical properties identical to authentic PAF-acether. Our results demonstrate that, although PAF-acether is produced mainly from pro-inflammatory cells, it appears to be produced even in tumour cells. |
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