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The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts |
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| Authors: | Richard A. Levy Richard E. Ostlund Jr. Janina Brajtburg |
| Affiliation: | (1) Divisions of Metabolism and Infectious Diseases, Department of Medicine, Washington University School of Medicine, 600 South Euclid Ave., 63110 St. Louis, Missouri;(2) Present address: Department of Medicine, Hahnemann University, Broad and Vine Streets, 19102 Philadelphia, PA |
| Abstract: | Summary Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin. Portions of this work were presented at the Southern Regional Meeting of the American Federation for Clinical Research, January 1983. |
| Keywords: | amphotericin B lipids fibroblasts LDL receptor hydroxymethylglutarylcoenzyme A insulin |
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