A Multistep Process Gave Rise to RNA Polymerase IV of Land Plants |
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Authors: | Jie Luo Benjamin D Hall |
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Institution: | (1) Department of Biology, University of Washington, Seattle, WA 98195, USA |
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Abstract: | Since their discovery in Metazoa, the three nuclear RNA polymerases (RNAPs) have been found in fungi, plants, and diverse
protists. In all eukaryotes studied to date, RNAPs I, II, and III collectively transcribe all major RNAs made in the nucleus.
We have found genes for the largest subunit (RPD1/RPE1) of a new DNA-dependent RNAP, RNAP IV, in all major land plant taxa
and in closely related green algae. Genes for the second-largest subunit (RPD2) of this enzyme were found in all land plants.
Phylogenetic study indicates that RNAP IV genes are sister to the corresponding RNAP II genes. Our results show the genesis
of RNAP IV to be a multistep process in which the largest and second-largest subunit genes evolved by independent duplication
events in the ancestors of Charales and land plants. These findings provide insights into evolutionary mechanisms that can
explain the origin of multiple RNAPs in the eukaryotic nucleus.
Electronic Supplementary Material Electronic Supplementary material is available for this article at
and accessible for authorised users.
Reviewing Editor: Dr. Patrick Keeling] |
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Keywords: | RNA polymerase IV RPD1 RPE1 RPD2 |
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