Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes |
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| Authors: | N M Scherer J E Ferguson |
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| Affiliation: | 1. Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA, United States;2. Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, United States;3. Department of Engineering Systems and Environment, University of Virginia, Charlottesville, VA, United States;1. Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo 11795, Egypt;2. Pretreatment and Finishing of Cellulosic Fibers, Textile Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza 12311, Egypt |
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| Abstract: | Regulation of many cell systems has been shown to be mediated by Inositol 1,4,5-trisphosphate which causes a release of calcium from intracellular sites. We have shown that release of Ca2+ from sarcoplasmic reticulum microsomes was not stimulated by IP3. The phorbol ester, TPA, also had no effect on Ca2+ release or Ca2+ ATPase activity. Thus, it is unlikely that the breakdown of polyphosphatidylinositides serves as a second messenger to mediate release of Ca2+ in skeletal muscle. |
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