Staurosporine, a protein kinase C inhibitor, attenuates Ca2+-dependent stretch-induced vascular tone |
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Authors: | I Laher J A Bevan |
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Institution: | Department of Pharmacology, University of Vermont, Burlington 05405. |
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Abstract: | The effects of protein kinase C inhibition by staurosporine was studied on Ca-dependent tone of the rabbit facial vein. Tone was produced either by stretch or by readmission of Ca2+ in a non-depolarizing Ca2+-free salt solution. Stretch-induced tone was inhibited by staurosporine. When tissues were incubated in a Ca2+-free solution, staurosporine (50 nM) inhibited the contractile responses produced by readmission of Ca2+. These observations suggest that maintenance of stretch-induced extracellular Ca2+-dependent tone may be regulated by protein kinase C. |
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