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Identification of a novel series of selective 5-HT7 receptor antagonists |
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| Authors: | Forbes Ian T Cooper David G Dodds Emma K Douglas Sara E Gribble Andrew D Ife Robert J Lightfoot Andrew P Meeson Malcolm Campbell Lorraine P Coleman Tanya Riley Graham J Thomas David R |
| Institution: | GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. |
| Abstract: | Novel 5-HT(7) receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Molecular modelling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound (25), SB-691673. |
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